Post by Tukuler on Mar 9, 2017 22:25:59 GMT -5
European Journal of Human Genetics 25, 472-476 (April 2017) | doi:10.1038/ejhg.2016.200
Miguel M Álvarez-Álvarez
Daniela Zanetti
Robert Carreras-Torres
Pedro Moral
Georgios Athanasiadis
A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease
Abstract
This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease.
A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples.
The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture.
Our results confirm the potentially important role of human demographic history when performing epidemiological studies.
Miguel M Álvarez-Álvarez
Daniela Zanetti
Robert Carreras-Torres
Pedro Moral
Georgios Athanasiadis
A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease
Abstract
This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease.
A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples.
The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture.
Our results confirm the potentially important role of human demographic history when performing epidemiological studies.