End of growing old?

[djoser-xyyman]

Genetic and epigenetic regulation of human aging and longevity☆
Author links open overlay panelBrian J.MorrisabcBradley J.WillcoxbcTimothy A.Donlonbd
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doi.org/10.1016/j.bbadis.2018.08.039Get rights and content
Highlights
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Genome-wide studies have implicated 57 gene loci in lifespan.

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Epigenomic changes during aging profoundly affect cell function and stress resistance.

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Dysregulation of transcriptional and chromatin networks is a crucial to aging.

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Breakdown in chromatin connectivity results in inappropriate gene expression.

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Epigenetic drift to an entopic middle ground means previously inactive genes “leak”.


Abstract
Here we summarize the latest data on genetic and epigenetic contributions to human aging and longevity. Whereas environmental and lifestyle factors are important at younger ages, the contribution of genetics appears more important in reaching extreme old age. Genome-wide studies have implicated ~57 gene loci in lifespan. Epigenomic changes during aging profoundly affect cellular function and stress resistance. Dysregulation of transcriptional and chromatin networks is likely a crucial component of aging. Large-scale bioinformatic analyses have revealed involvement of numerous interaction networks. As the young well-differentiated cell replicates into eventual senescence there is drift in the highly regulated chromatin marks towards an entropic middle-ground between repressed and active, such that genes that were previously inactive “leak”. There is a breakdown in chromatin connectivity such that topologically associated domains and their insulators weaken, and well-defined blocks of constitutive heterochromatin give way to generalized, senescence-associated heterochromatin, foci. Together, these phenomena contribute to aging.

Graphical abstract

[kel]

a slow down yes......possible.

[anansi]

What about the social cost of longevity.

[nebsen]

Sept 10, 2018 12:47:15 GMT -5 anansi said:

What about the social cost of longevity.

It's strange how many esp in the west are afraid of death; a natural part of living a part of the great cycle in one life; i once read years ago that ancestors ancient Egyptian would bring small coffins to festive affairs to remind each other with humor that part cycle of ones life & party hard.Entering my early 70's is truly a adventure, & journey, I welcome it, with great curiosity, &wonder, I'm grateful to be alive to witness these times that will be written & talked about hundreds of years from now; As the song says" when it's your time to move, it's your time" !!

[nebsen]

Cassandra Wilson says it best,check it out !

[djoser-xyyman]

Social cost? One solution is...have less kids. Don't like it....but



© BioMed Central
Quote:

The research builds on earlier findings that showed ‘splicing factor’ genes switch off as humans age. Scientists found a way to restart the splicing through chemicals.

According to the researchers, this could change the way we age, with the hope that humans will experience less of the degeneration that comes with aging. Older people are more likely to have strokes, heart disease and other illnesses, but with cell rejuvenation, this could be decreased.

“This demonstrates that when you treat old cells with molecules that restore the levels of the splicing factors, the cells regain some features of youth,” team leader Professor Lorna Harries said. They are able to grow, and their telomeres - the caps on the ends of the chromosomes that shorten as we age - are now longer, as they are in young cells. Far more research is needed now, to establish the true potential for these sort [sic] of approaches to address the degenerative effects of ageing. ”

www.rt.com/news/409314-old-cell-rejuvenation-breakthrough/