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Post by djoser-xyyman on Mar 3, 2020 21:12:13 GMT -5
Evaluating the promise of inclusion of African ancestry populations in genomics Amy R. Bentley, Shawneequa L. Callier & Charles N. Rotimi npj Genomic Medicine volume 5, Article number: 5 (2020) Cite this article
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Abstract The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are becoming increasingly appreciated. The paucity of data on individuals with African ancestry is especially noteworthy as Africa is the birthplace of modern humans and harbors the greatest genetic diversity. It is expected that greater representation of those with African ancestry in genomic research will bring novel insights into human biology, and lead to improvements in clinical care and improved understanding of health disparities. Now that major efforts have been undertaken to address this failing, is there evidence of these anticipated advances? Here, we evaluate the promise of including diverse individuals in genomic research in the context of recent literature on individuals of African ancestry. In addition, we discuss progress and achievements on related technological challenges and diversity among scientists conducting genomic research.
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Post by mansamusa on Mar 20, 2020 4:32:06 GMT -5
New study: Insights into human genetic variation and population history from 929 diverse genomes"Genomic sequencing of diverse human populations to understand overall genetic diversity has lagged behind in-depth examination of specific populations. To add to our understanding of human genetic diversity, Bergström et al. generated whole-genome sequences surveying individuals in the Human Genome Diversity Project, which is a panel of global populations that has been instrumental in understanding the history of human populations. The authors' study adds data about African, Oceanian, and Amerindian populations and indicates that diversity tends to result from differences at the single-nucleotide level rather than copy number variation. An analysis of archaic sequences in modern populations identifies ancestral genetic variation in African populations that likely predates modern humans and has been lost in most non-African populations." So is archaic ancestry in Africa real or not? "We found small amounts of Neanderthal ancestry in West African genomes, most likely reflecting Eurasian admixture. Despite their very low levels or absence of archaic ancestry, African populations share many Neanderthal and Denisovan variants that are absent from Eurasia, reflecting how a larger proportion of the ancestral human variation has been maintained in Africa."
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Post by thereal on Mar 20, 2020 7:33:49 GMT -5
Wtf? That highlighted part conflicts with the first part of that sentence.
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Post by kel on Mar 20, 2020 15:25:33 GMT -5
hahahhahaha
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Post by djoser-xyyman on Mar 22, 2020 6:47:59 GMT -5
lol! These people are manic. They write or make contradictory statements all the time and in their minds it makes perfect sense. VMAT1 gene at work.
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Post by kel on Mar 28, 2020 14:58:54 GMT -5
U r indeed correct.
VMAT run amok !!!!
Any forthcoming cures perhaps ?
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