Post by djoser-xyyman on Sept 2, 2010 12:14:18 GMT -5
On the basis of a sample of 117 chromosomes, we have demonstrated the multicentric
origin of the sickle mutation in Northern Oman. Three major haplotypes coexist: 52.1%
Benin (typical and atypicals), 26.7% Arab-India, and 21.4% Bantu. These haplotypes are
not autochthonous to Oman but originated elsewhere and arrived in Oman by gene flow.
The distribution of haplotypes is in excellent agreement with the historical record, which
establishes clear ancient contacts between Oman and sub-Sahara west Africa and explains
the presence of the Benin haplotype; contacts with Iraq, Iran, present-day Pakistan,
and India explain the presence of the Arab-India haplotype. More recent contacts
with East Africa (Zanzibar/Mombasa) explain the presence of the Bantu haplotype. The
pattern of the Arab-India haplotype in the populations of the Arabian peninsula reinforces
the hypothesis that this particular mutation originated in the Harappa culture or in a
nearby population and in addition reveals that the Sassanian Empire might have been the
vehicle by which this Indo-European sickle mutation migrated (gene flow) to the presentday
Arabian peninsula, including Oman. Am. J. Hematol. 64:39–46, 2000.
ipac.kacst.edu.sa/eDoc/2007/166399_1.pdf
origin of the sickle mutation in Northern Oman. Three major haplotypes coexist: 52.1%
Benin (typical and atypicals), 26.7% Arab-India, and 21.4% Bantu. These haplotypes are
not autochthonous to Oman but originated elsewhere and arrived in Oman by gene flow.
The distribution of haplotypes is in excellent agreement with the historical record, which
establishes clear ancient contacts between Oman and sub-Sahara west Africa and explains
the presence of the Benin haplotype; contacts with Iraq, Iran, present-day Pakistan,
and India explain the presence of the Arab-India haplotype. More recent contacts
with East Africa (Zanzibar/Mombasa) explain the presence of the Bantu haplotype. The
pattern of the Arab-India haplotype in the populations of the Arabian peninsula reinforces
the hypothesis that this particular mutation originated in the Harappa culture or in a
nearby population and in addition reveals that the Sassanian Empire might have been the
vehicle by which this Indo-European sickle mutation migrated (gene flow) to the presentday
Arabian peninsula, including Oman. Am. J. Hematol. 64:39–46, 2000.
ipac.kacst.edu.sa/eDoc/2007/166399_1.pdf
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