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Post by djoser-xyyman on Sept 18, 2016 12:27:12 GMT -5
Again I ask. Did you look at and understand those youtube videos?
Do you understand why La Braña is closest to Onge and NOT modern Europeans? This is not me saying this is the researchers. Do you understand that and why?. Should I continue or do you want me to stop educate you? This is a teaching moment. Do you understand WHY La Braña is not a modern European irregardless of blue eyes.
Only a two year old thinks all blue cars is a Ford. LOL! Do you understand that? Should I continue?
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Post by zarahan on Sept 18, 2016 18:46:32 GMT -5
I see a massive number of duplicates from this user cutting across many threads.
The "Cucasoid Cro-Magnon" video for example has appeared at least 9 times in 5 different
threads, a majority having little relation to the thread. He is copying and pasting the
exact same material to dump across multiple threads. There is no real discussion going
on.
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Post by lazarus on Sept 21, 2016 5:58:54 GMT -5
Again I ask. Did you look at and understand those youtube videos? Do you understand why La Braña is closest to Onge and NOT modern Europeans? This is not me saying this is the researchers. Do you understand that and why?. Should I continue or do you want me to stop educate you? This is a teaching moment. Do you understand WHY La Braña is not a modern European irregardless of blue eyes. Only a two year old thinks all blue cars is a Ford. LOL! Do you understand that? Should I continue? READ VERY SLOWLY: HAPLOGROUP CF ORIGINATED with the CRO-MAGNON man in the MIDDLE EAST and was taken into INDIA where it became C and F ONE GROUP CARRYING C then went into EUROPE THE OTHER GROUP carrying C then went into ASIA, AUSTRALIA! GOT IT SO FAR?  LABRANA MAN CARRIED THE VERY VERY INDIGENOUS EUROPEAN HAPLOGROUP C6! HE WAS AN INDIGENOUS EUROPEAN! ONGE and all ANDAMANESE DO NOT CARRY HAPLOGROUP C, but carry D-M174 and M31, M32 THEY ARE NOT RELATED TO EUROPEANS and NEVER EVER WERE! |
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Post by djoser-xyyman on Sept 21, 2016 12:21:54 GMT -5
Psst. Do you understand how the haplotree is formed or constructed? Do you understand the relationship between autosomal SNP and Sex related haplogroups? Really La Braña is Related to Onge. Did you look at the Cluster charts posted by the author? Did you read and understand the paper . This was covered here on ESR. Really. Lol! Tsk! Tsk! These young punks trying to sew their oats.SMH
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Post by djoser-xyyman on Sept 21, 2016 13:57:30 GMT -5
This is for the newbies reading this. Not for the dogmatic rabble rousers who are posting on stuff they don’t fully understand. Excerpts from the ACTUAL Research paper NOT from Wiki or Youtube or a blogger. Lol! Again, don’t get caught up in the media hype ‘brown” skin. It is all “spin”. lol. La Brana has the genetic pigmentation configuration as Melanesians and Neanderthal who was also black skinned. Read the research on Neanderthal!!! You people are coming out the wood works but what is irritating is you have no clue.
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European - In˜igo Olalde1*, Carles Lalueza-Fox1
Quote from the study
----
Of the ten variants, the Mesolithic genome (La Brana) carried the ancestral and non-selected allele as a homozygote in three regions:C12orf29 (a gene with
unknown function), SLC45A2 (rs16891982) and SLC24A5 (rs1426654) (Table 1). The latter two variants are the two strongest known loci
affecting light skin pigmentation in Europeans20–22 and their ancestral alleles and associated haplotypes are either absent or segregate at very
low frequencies in extant Europeans (3% and 0% for SLC45A2 and SLC24A5, respectively) (Fig. 2). We subsequently examined all genes
known to be associated with pigmentation in Europeans22, and found ancestral alleles in MC1R, TYR and KITLG, and derived alleles in
TYRP1, ASIP and IRF4 (Supplementary Information). Although the precise phenotypic effects cannot currently be ascertained in a European
genetic background, results from functional experiments20 indicate that the allelic combination in this Mesolithic individual is likely to have
resulted in dark skin pigmentation and dark or brown hair. Further examination revealed that this individual carried the HERC2 rs12913832*C
single nucleotide polymorphism (SNP) and the associated homozygous haplotype spanning the HERC2–OCA2 locus that is strongly associated
with blue eye colour23. Moreover, a prediction of eye colour based on genotypes at additional loci using HIrisPlex24 produced a 0.823 maximal
and 0.672 minimal probability for being non-brown-eyed (Supplementary Information). The genotypic combination leading to a predicted
phenotype of dark skin and non-brown eyes is unique and no longer present in contemporary European populations. Our results indicate
that the adaptive spread of light skin pigmentation alleles was not complete in some European populations by the Mesolithic, and that
the spread of alleles associated with light/blue eye colour may have preceded changes in skin pigmentation.
----
La Brana was black like Melanesians and had no-brown eyes. They are not sure of the color but they are sure it was not brown. So saying he had blue eyes is also a lie. Don’t you get that?
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Post by djoser-xyyman on Sept 21, 2016 14:06:52 GMT -5
This is for the newbies reading this. Not for the dogmatic rabble rousers who are posting on stuff they don’t fully understand. Excerpts from the ACTUAL Research paper NOT from Wiki or Youtube or a blogger. Lol! Again, don’t get caught up in the media hype ‘brown” skin. It is all “spin”. lol. La Brana has the genetic pigmentation configuration as Melanesians and Neanderthal who was also black skinned. Read the research on Neanderthal!!! You people are coming out the wood works but what is irritating is you have no clue.
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European - In˜igo Olalde1*, Carles Lalueza-Fox1
Quote from the study
----
Of the ten variants, the Mesolithic genome (La Brana) carried the ancestral and non-selected allele as a homozygote in three regions:C12orf29 (a gene with
unknown function), SLC45A2 (rs16891982) and SLC24A5 (rs1426654) (Table 1). The latter two variants are the two strongest known loci
affecting light skin pigmentation in Europeans20–22 and their ancestral alleles and associated haplotypes are either absent or segregate at very
low frequencies in extant Europeans (3% and 0% for SLC45A2 and SLC24A5, respectively) (Fig. 2). We subsequently examined all genes
known to be associated with pigmentation in Europeans22, and found ancestral alleles in MC1R, TYR and KITLG, and derived alleles in
TYRP1, ASIP and IRF4 (Supplementary Information). Although the precise phenotypic effects cannot currently be ascertained in a European
genetic background, results from functional experiments20 indicate that the allelic combination in this Mesolithic individual is likely to have
resulted in dark skin pigmentation and dark or brown hair. Further examination revealed that this individual carried the HERC2 rs12913832*C
single nucleotide polymorphism (SNP) and the associated homozygous haplotype spanning the HERC2–OCA2 locus that is strongly associated
with blue eye colour23. Moreover, a prediction of eye colour based on genotypes at additional loci using HIrisPlex24 produced a 0.823 maximal
and 0.672 minimal probability for being non-brown-eyed (Supplementary Information). The genotypic combination leading to a predicted
phenotype of dark skin and non-brown eyes is unique and no longer present in contemporary European populations. Our results indicate
that the adaptive spread of light skin pigmentation alleles was not complete in some European populations by the Mesolithic, and that
the spread of alleles associated with light/blue eye colour may have preceded changes in skin pigmentation.
----
La Brana was black like Melanesians and had non-brown eyes. They are not sure of the color but they are sure it was NOT brown. So saying he had blue eyes is also a lie. Don’t you get that?
Now…an intelligent person who understand this stuff instead of relying on Wiki may asking why I am stating black like Melanesian/Onge and not black like modern Africans? Do you want to know or understand why? Because Africans carry MORE variability(derived and underived) around these locus than Melanesians/Onge. Meaning Africans carry genes capable of producing light skin unlike Onge/Melanesians. But you don’t understand that. To the newbies. Look at Fig 2 of the study for La Brana cited above. YRI vs CEU vs La Brana1. See the red vs blue. Notice YRI has a greater variability around the SLC45A2 and SLC24A5 locus. Get it?!! Now would you STFU and take your rant someplace else. Thanks! SMH.
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Post by djoser-xyyman on Sept 21, 2016 14:32:56 GMT -5
Again. This is for the newbies reading this. I have gone over this several times over the last coupls of years. I hate re-hashing but….
Here are the relevant quotes to understand La Brana was black skin but bot closely related to modern Europeans and YRI(Yorubans). La Brana is part of the same group that carried Asian haplogroup-C to Asia but split off into Southern Europe.
----
The fact that we found ancestral alleles in mutations defining C1, C2, C3 and C4 (Table S9), together with their actual phylogeographic distribution restricted to Asia, Oceania and the Americas suggests that our individual does not belong to any of these branches. Rather, a new branch within haplogroup C (C6, originally named C7) has recently been identified in several men from Southern Europe, suggesting this could be an ancient European clade51. Importantly, mutation V20 showed one read with the derived allele (A), which points to C6 as the most probable sub-clade for La Braña 1 sample. It could also be possible that this G to A mutation is a result of DNA damage. Other less likely haplogroup affiliations are C* and C5 (no read covered SNP M356), both found mainly in present-day India. Besides the V20 mutation, four other positions could have potentially been assigned wrongly due to the presence of DNA damage. However, their allele state is phylogenetically coherent with the rest of the SNPs studied. The precise affiliation of La Braña 1 in the Y-chromosome phylogeny could be better determined in the future with more data and increased genomic coverage.
Further, though the comparison between Sardinians and the Mal’ta samples suggests that the Mal’ta individual is closer to the La Braña 1 ample than it is to any of the other modern European populations. We now examine this affinity of the Mal’ta and La Braña 1 individuals further.
Hence, the Mesolithic hunter-gatherer population, to which the La Braña 1 individuals belonged, was probably lactose intolerant.
We analyzed a window of around 40 variants at each side of the selected SNPs and analyzed their allele frequencies in extant CEU and YRI and compared them with La Braña 1 genotypes (Figure 2). For rs16891982 and rs1426654 most neighboring SNPs that are segregating in YRI appear fixed in CEU, while La Braña 1 carries genotypes not compatible with the present European’s at many sites. On the contrary, combinations of alleles for these SNPs found in La Braña 1 can be present in the extant YRI population, which suggests that those sites with ancestral alleles are not back mutations, but that the Mesolithic sample contains partial ancestral haplotypes.
-----
La Brana was part of the initial OOA black population that migrated to Europe instead of Asia. Lol! You are such a dummy.
Now! Go read the fugkinh study your self instead of doing google searches and using wiki. lol!
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Post by lazarus on Sept 22, 2016 6:05:02 GMT -5
This is for the newbies reading this. Not for the dogmatic rabble rousers who are posting on stuff they don’t fully understand. Excerpts from the ACTUAL Research paper NOT from Wiki or Youtube or a blogger. Lol! Again, don’t get caught up in the media hype ‘brown” skin. It is all “spin”. lol. La Brana has the genetic pigmentation configuration as Melanesians and Neanderthal who was also black skinned. Read the research on Neanderthal!!! You people are coming out the wood works but what is irritating is you have no clue. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European - In˜igo Olalde1*, Carles Lalueza-Fox1 Quote from the study ---- Of the ten variants, the Mesolithic genome (La Brana) carried the ancestral and non-selected allele as a homozygote in three regions:C12orf29 (a gene with unknown function), SLC45A2 (rs16891982) and SLC24A5 (rs1426654) (Table 1). The latter two variants are the two strongest known loci
affecting light skin pigmentation in Europeans20–22 and their ancestral alleles and associated haplotypes are either absent or segregate at very low frequencies in extant Europeans (3% and 0% for SLC45A2 and SLC24A5, respectively) (Fig. 2). We subsequently examined all genes
known to be associated with pigmentation in Europeans22, and found ancestral alleles in MC1R, TYR and KITLG, and derived alleles in TYRP1, ASIP and IRF4 (Supplementary Information). Although the precise phenotypic effects cannot currently be ascertained in a European genetic background, results from functional experiments20 indicate that the allelic combination in this Mesolithic individual is likely to have resulted in dark skin pigmentation and dark or brown hair. Further examination revealed that this individual carried the HERC2 rs12913832*C single nucleotide polymorphism (SNP) and the associated homozygous haplotype spanning the HERC2–OCA2 locus that is strongly associated with blue eye colour23. Moreover, a prediction of eye colour based on genotypes at additional loci using HIrisPlex24 produced a 0.823 maximal and 0.672 minimal probability for being non-brown-eyed (Supplementary Information). The genotypic combination leading to a predicted phenotype of dark skin and non-brown eyes is unique and no longer present in contemporary European populations. Our results indicate that the adaptive spread of light skin pigmentation alleles was not complete in some European populations by the Mesolithic, and that the spread of alleles associated with light/blue eye colour may have preceded changes in skin pigmentation. ---- La Brana was black like Melanesians and had no-brown eyes. They are not sure of the color but they are sure it was not brown. So saying he had blue eyes is also a lie. Don’t you get that? |
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Post by lazarus on Sept 22, 2016 6:34:00 GMT -5
This is for the newbies reading this. Not for the dogmatic rabble rousers who are posting on stuff they don’t fully understand. Excerpts from the ACTUAL Research paper NOT from Wiki or Youtube or a blogger. Lol! Again, don’t get caught up in the media hype ‘brown” skin. It is all “spin”. lol. La Brana has the genetic pigmentation configuration as Melanesians and Neanderthal who was also black skinned. Read the research on Neanderthal!!! You people are coming out the wood works but what is irritating is you have no clue. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European - In˜igo Olalde1*, Carles Lalueza-Fox1 Quote from the study ---- Of the ten variants, the Mesolithic genome (La Brana) carried the ancestral and non-selected allele as a homozygote in three regions:C12orf29 (a gene with unknown function), SLC45A2 (rs16891982) and SLC24A5 (rs1426654) (Table 1). The latter two variants are the two strongest known loci
affecting light skin pigmentation in Europeans20–22 and their ancestral alleles and associated haplotypes are either absent or segregate at very low frequencies in extant Europeans (3% and 0% for SLC45A2 and SLC24A5, respectively) (Fig. 2). We subsequently examined all genes
known to be associated with pigmentation in Europeans22, and found ancestral alleles in MC1R, TYR and KITLG, and derived alleles in TYRP1, ASIP and IRF4 (Supplementary Information). Although the precise phenotypic effects cannot currently be ascertained in a European genetic background, results from functional experiments20 indicate that the allelic combination in this Mesolithic individual is likely to have resulted in dark skin pigmentation and dark or brown hair. Further examination revealed that this individual carried the HERC2 rs12913832*C single nucleotide polymorphism (SNP) and the associated homozygous haplotype spanning the HERC2–OCA2 locus that is strongly associated with blue eye colour23. Moreover, a prediction of eye colour based on genotypes at additional loci using HIrisPlex24 produced a 0.823 maximal and 0.672 minimal probability for being non-brown-eyed (Supplementary Information). The genotypic combination leading to a predicted phenotype of dark skin and non-brown eyes is unique and no longer present in contemporary European populations. Our results indicate that the adaptive spread of light skin pigmentation alleles was not complete in some European populations by the Mesolithic, and that the spread of alleles associated with light/blue eye colour may have preceded changes in skin pigmentation. ---- La Brana was black like Melanesians and had non-brown eyes. They are not sure of the color but they are sure it was NOT brown. So saying he had blue eyes is also a lie. Don’t you get that? Now…an intelligent person who understand this stuff instead of relying on Wiki may asking why I am stating black like Melanesian/Onge and not black like modern Africans? Do you want to know or understand why? Because Africans carry MORE variability(derived and underived) around these locus than Melanesians/Onge. Meaning Africans carry genes capable of producing light skin unlike Onge/Melanesians. But you don’t understand that. To the newbies. Look at Fig 2 of the study for La Brana cited above. YRI vs CEU vs La Brana1. See the red vs blue. Notice YRI has a greater variability around the SLC45A2 and SLC24A5 locus. Get it?!! Now would you STFU and take your rant someplace else. Thanks! SMH. |
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Post by djoser-xyyman on Sept 22, 2016 11:38:26 GMT -5
You are watching too much WWF. Psssst. Wrestlin is NOT real! Really, it is not! Lol! So, did you ever read the study on the genetic profile of Neanderthal? Newsflash!! It is available on line and posted on here ESR. And yes, Neanderthal carry ANCESTRAL forms of pigmentation genes just as Africans, Melenesians......and La Brana. SMH. Why am I wasting my time talking to a novice like you ? Tsk! Tsk!
Tell you what, stop watching racist TV, National Geography Channel and the like is designed for suckers like you to spend money on bullshyt fantasy. You wouldn't spend money on a DNA kit or Smithsonian if you knew Neanderthal was black, would you ....sucker. There is one born everyday. Go ahead with your bad self. Google and wiki instead of reading the actual study to get your information. YouTube is for suckers like you. Smh.
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Post by djoser-xyyman on Sept 22, 2016 11:45:59 GMT -5
You are posting youtube stuff you either haven't looked at or do NOT understand. Most of what you referenced do NOT support you point of view. Lol!
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Post by djoser-xyyman on Sept 22, 2016 11:59:02 GMT -5
That’s the problem with you young punks. You are dumb as a doorknob. You only learn through pictures. Don’t understand the science behind these studies. First Neanderthal never had red hair or light eyes. 10years ago there was speculation about red hair based upon the MC1r gene in red headed Europeans that has since been CORRECTED. Dumb punk. Why! Because they later found out the MC1r gene on humans and Neanderthal are on a DIFFERENT locus. Fool. Read and referenced up-to-date studies. If you a serious about learning instead spewing BS from that mouth of yours. Get your hands on the research papers. They are posted here on ESR or STFU on things you don’t fully understand.
Here!!! Tell me what think of this. It is not on Youtube as yet. Lol! Published Setp2016!!!!
Mallick et al., The Simons Genome Diversity Project: 300 genomes from 142 diverse populations,
Abstract: Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
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Post by djoser-xyyman on Sept 22, 2016 12:30:06 GMT -5
To those newbies who are missing the salient point. What they are saying is that irregardless of what Eurasians(Not including Western Europeans who are primarily modern Africans) “look” like they came from ONE common stock that left OOA. So in other words Negros of Asia like Onge, Melenesians, Paupan etc, Han, Koreans, Native Americans, Central Asian. They all came from ONE common African population >50,000ya. Yet they “look” so different now. Pictures do NOT tell a thousand words. Lol! Fool. Science does!
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dingo
Craftsperson
duplicate account of "Jethro" using same spam
Posts: 21 
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Post by dingo on Sept 23, 2016 7:32:21 GMT -5
Psst. Do you understand how the haplotree is formed or constructed? Do you understand the relationship between autosomal SNP and Sex related haplogroups? Really La Braña is Related to Onge. Did you look at the Cluster charts posted by the author? Did you read and understand the paper . This was covered here on ESR. Really. Lol! Tsk! Tsk! These young punks trying to sew their oats.SMH Europeans, Middle Eastern People look like Cro-Magnon and Neanderthals and nothing like Black Africans! END of STORY! |
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dingo
Craftsperson
duplicate account of "Jethro" using same spam
Posts: 21
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Post by dingo on Sept 23, 2016 7:34:25 GMT -5
Psst. Do you understand how the haplotree is formed or constructed? Do you understand the relationship between autosomal SNP and Sex related haplogroups? Really La Braña is Related to Onge. Did you look at the Cluster charts posted by the author? Did you read and understand the paper . This was covered here on ESR. Really. Lol! Tsk! Tsk! These young punks trying to sew their oats.SMH Europeans, Middle Eastern People look like Cro-Magnon and Neanderthals and nothing like Black Africans or ONGE or Chines or anything else! END of STORY! CRO-MAGNON looking 100% exactly like MODERN EUROPEANS carrying the EXACT SAME DNA: |
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