Post by Charlie Bass on Nov 29, 2011 4:09:31 GMT -5
www.uvm.edu/~rsingle/other/PDF/Cao+TA-2004.pdf
The Ugandan population presents the alleles B*4402G and Cw*0501G with frequencies significantly higher than the other African populations in this study. These alleles form the extended haplotype A*0201G-B*4402G-Cw*0501G, which is frequently found in Caucasians; their finding in Ugandans, combined with the frequent observation in this population of haplotypes commonly found in Caucasoids and the closer genetic distances between Caucasians and Ugandans (Table 6), could indicate a recent gene flow of Caucasian or North African genes into the Ugandan population. This observation could explain the greater allelic and haplotypic HLA diversity of the Ugandan population.
Opposing the view of recent admixture, it could be argued that, as has been shown for other loci in the geographically close populations from Ethiopia and Somalia (110–113), the Ugandans present a subset of the variability that is present in other sub-Saharan African populations. Some populations in north-east Africa might have diverged from the rest of sub-Saharan Africa, early in the history of modern African populations; a subset of this north-east African population may have then migrated out of Africa and populated other regions of the world (110–114). Studies of mitochondrial DNA (4, 6, 7, 115) and Y-chromosome diversity (116–119) in other populations, and the distribution of HLA alleles in Ugandans reported here are consistent with
the hypothesis of the migration of modern humans out of an East
African population. The absence of the widely distributed African
haplotype A*3001-B*4201-Cw*1701G in Ugandans may reflect an
early differentiation between Ugandans and other African populations.
Opposing the view of recent admixture, it could be argued that, as has been shown for other loci in the geographically close populations from Ethiopia and Somalia (110–113), the Ugandans present a subset of the variability that is present in other sub-Saharan African populations. Some populations in north-east Africa might have diverged from the rest of sub-Saharan Africa, early in the history of modern African populations; a subset of this north-east African population may have then migrated out of Africa and populated other regions of the world (110–114). Studies of mitochondrial DNA (4, 6, 7, 115) and Y-chromosome diversity (116–119) in other populations, and the distribution of HLA alleles in Ugandans reported here are consistent with
the hypothesis of the migration of modern humans out of an East
African population. The absence of the widely distributed African
haplotype A*3001-B*4201-Cw*1701G in Ugandans may reflect an
early differentiation between Ugandans and other African populations.